A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/00 (2006.01) A61K 9/127 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/70 (2006.01) A61K 31/137 (2006.01) A61K 31/165 (2006.01) A61K 47/18 (2006.01)
Patent
CA 2403958
Novel pharmaceutical kit comprising controlled release pharmaceutical compositions for oral use containing midodrine and/or its active metabolite desglymidodrine and a relatively fast onset composition. The controlled release compositions are designed to release midodrine and/or desglymidodrine after oral intake in a manner which enables absorption to take place in the gastrointestinal tract so that a relatively fast peak plasma concentration of the active metabolite desglymidodrine is obtained followed by a prolonged and relatively constant plasma concentration of desglymidodrine. Also disclosed is a method for treated orthostatic hypotention and/or urinary incontinence, the method comprising administration to a patient in need thereof of an effective amount of midodrine and/or desglymidodrine in a kit according to the invention.
L'invention concerne une nouvelle composition pharmaceutique comportant des compositions préparations pharmaceutiques à diffusion contrôlée pour une utilisation orale contenant de la midodrine et/ou son métabolite actif le desglymidodrine et une préparation à effet retard relativement rapide. Les préparations à diffusion contrôlée sont conçues pour diffuser la midodrine et/ou le desglymidodrine après ingestion orale, d'une façon telle qu'elle permet à l'absorption de se produire dans le tractus gastro-intestinal, de manière à ce qu'un pic de concentration de plasma du métabolite actif desglymidodrine soit obtenu relativement rapidement suite à une concentration de plasma de desglymidodrine relativement constante et prolongée. L'invention concerne également un procédé de traitement de l'hypotension orthostatique et/ou de l'incontinence urinaire. Ce procédé comporte l'administration à un patient souffrant de ces troubles d'une quantité efficace de midodrine et/ou de desglymidodrine dans une composition conformément à la présente invention.
Bertelsen Poul
Olsen Peder Mohr
Skinhoj Annette
Nycomed Austria Gmbh
Sim & Mcburney
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