Pharmaceutical microencapsulation

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 11/04 (2006.01) A61K 9/50 (2006.01) A61K 9/66 (2006.01) A61K 35/39 (2006.01) A61L 27/00 (2006.01) A61L 27/38 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2216359

A method of producing a microencapsulated pharmaceutical formulation is disclosed comprising causing a dye to be attached to the surface of pharmaceutical particles or particle clusters and applying a source of radiant energy to the dye in the presence of a liquid polymeric or polymerisable material so as to cause the material to cross-link, producing a conformal layer of cross-linked polymer on the particulate surfaces. Preferably, the polymer provides an immuno-protective layer around the particles. while allowing therapeutic components to exit the microcapsules. Microencapsulated pharmaceutical formulations and their medical use are also disclosed, especially for the treatment of diabetes by encapsulating insulin secreting cells.

Procédé de production d'une formule pharmaceutique micro-encapsulée, consistant à fixer un colorant à la surface de particules ou d'agglomérats de particules pharmaceutiques et à appliquer une source d'énergie de rayonnement à la teinture, en présence d'une substance polymère ou polymérisable liquide, de façon à provoquer la réticulation du matériau, ce qui crée une couche conforme de polymère réticulé sur la surface des particules. De préférence, le polymère constitue une couche immuno-protectrice autour des particules, tout en permettant aux composants thérapeutiques de sortir des micro-capsules. Sont également décrits des préparations pharmaceutiques micro-encapsulées et leur usage médical, concernant en particulier le traitement du diabète par encapsulage de cellules sécrétant de l'insuline.

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