A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/24 (2006.01)
Patent
CA 2573705
The present invention relates to a pharmaceutical controlled release multilayer tablet comprising at least two layers, at least one active ingredient with highly pH-dependent solubility, at least one pharmaceutically acceptable pH maintaining excipient and at least one pharmaceutically acceptable matrix forming excipient, characterized in that said at least one active ingredient with highly pH-dependent solubility and said at least one pharmaceutically acceptable pH maintaining excipient are respectively comprised in at least one distinct layer.
La présente invention concerne un comprimé pharmaceutique multicouche à libération lente, qui comprend au moins deux couches, au moins un principe actif dont la solubilité est fortement tributaire du pH, au moins un excipient de maintien du pH pharmaceutiquement acceptable, et au moins un excipient de formation de matrice pharmaceutiquement acceptable. Le comprimé se caractérise en ce que le(s) principe(s) actif(s) dont la solubilité est fortement tributaire du pH et l'excipient (les excipients) de maintien du pH pharmaceutiquement acceptable(s) sont respectivement inclus dans au moins une couche distincte.
Bruel Jean-Luc
Cuine Alain
Roger Benedicte
Robic
Sanofi-Aventis
LandOfFree
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