A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/23 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 9/12 (2006.01) A61K 47/06 (2006.01) C07K 14/585 (2006.01) G01N 33/15 (2006.01) A61K 38/00 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01)
Patent
CA 2212520
The subject-matter of the invention are pharmaceutical non inorganic saline solutions for endonasal administration containing: (a) a calcitonin, preferably salmon or alternatively carbacalcitonin (elcatonin), or its pharmaceutically acceptable salts; characterized in that it further contains the organic excipients; (b) N-(methyl)-glucamine or glucamine; (c) tromethamine; (d) citric acid; and (e) polyvinylpyrrolidone ranging from K15 to K120. These are odourless and tasteless and thus have improved patient's compliance not having the undesirable secondary effects of known compositions as well as permit a complete and accurate analysis of the activeprinciple and develop less degradation products during storage.
L'invention porte sur des solutions pharmaceutiques salines non organiques à administration endonasale contenant: (a) de la calcitonine de préférence de saumon ou bien de la carbacalcitonine (elcatonine); ou leurs sels pharmacocompatibles et les excipients organiques suivants: (b) de la N-(méthyl)-glutamine ou glucamine; (c) de la trométhamine; (d) de l'acide citrique; et (e) de la polyvinylpyrrolidone allant de K15 à K120. Ces solutions inodores et insipides, donc plus agréables pour le patient, ne présentent pas les effets secondaires des compositions connues, permettent une analyse complète et précise de leurs principes actifs et développent moins de produits de dégradation pendant leur entreposage.
Peschechera Emanuela
Veronesi Anna Maria
Veronesi Paolo Alberto
Fetherstonhaugh & Co.
Therapicon S.r.l.
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