A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/496 (2006.01) A61K 9/16 (2006.01) A61K 9/30 (2006.01) A61K 47/38 (2006.01) A61P 31/10 (2006.01)
Patent
CA 2337509
Pharmaceutical preparation comprising a compound having an antifungic activity as active principle, an inert core and a coat which includes said active principle, and is characterized in that said inert core has a particle size between 50 and 600 µm, and is also characterized in that said coat has a unique layer which is produced by nebulization, on said inert core, of a solution which comprises a compound having an antifungic activity, a hydrophilic polymer and a non ionic surfactant. The method is carried out by means of a coating which comprises a unique layer of the inert cores having a size comprised between 50 and 600 µm by nebulization of a solution comprised of the antifungic agent, the hydrophilic polymer and the non ionic surfactant at constant coating speed throughout the process; a single drying process of the coat is required with the same equipment.
L'invention concerne une préparation pharmaceutique comprenant un composé à activité antifongique en tant que principe actif, un noyau inerte et un enrobage renfermant ce principe actif. Cette préparation est caractérisée en ce que ledit noyau inerte présente une granulométrie comprise entre 50 et 600 mu m et en ce que ledit enrobage présente une seule couche obtenue par nébulisation, sur ce noyau inerte, d'une solution renfermant un composé à activité antifongique, un polymère hydrophile et un agent tensioactif non ionique. Ce procédé est mis en oeuvre au moyen d'un enrobage comprenant une seule couche des noyaux inertes dont la granulométrie est comprise entre 50 et 600 mu m obtenue par nébulisation d'une solution constituée d'un agent antifongique, du polymère hydrophile et de l'agent tensioactif non ionique à une vitesse d'enrobage constante pendant tout le processus. Ce procédé consiste ensuite à sécher cet enrobage dans le même équipement.
Laboratorios Liconsa S.a.
Robic
S.a. Liconsa Liberacion Controlada de Sustancias Activas
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