Pharmaceutical parenteral composition containing a...

A - Human Necessities – 61 – K

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Details

A61K 31/663 (2006.01) A61K 31/167 (2006.01) A61K 31/675 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2406798

The present invention relates to a parenteral composition comprising a bisphosphonic acid or a pharmaceutically acceptable salt thereof (bisphosphonate) as active component and a pharmaceutically acceptable chelating agent, processes of the preparation of this composition, and methods of their use in the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, hypercalcemia of malignancy, and metabolic bone disease. The compositions are especially useful for improving the local tolerance of the active component when administered parenterally.

La présente invention concerne une composition parentérale contenant un acide bisphosphonique ou un de ses sels acceptables d'un point de vue pharmaceutique (bisphosphonate) comme agent actif, ainsi qu'un agent chélateur pharmaceutiquement acceptable. L'invention concerne également des méthodes de préparation de cette composition et des méthodes d'utilisation dans le traitement et la prévention de maladies impliquant la résorption osseuse, notamment l'ostéoporose, la maladie osseuse de Paget, l'hypercalcémie maligne et des maladies métaboliques osseuses. Ces compositions conviennent particulièrement pour améliorer la tolérance locale à l'agent actif lors de son administration par voie parentérale.

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