Pharmaceutical platform technology for the development of...

A - Human Necessities – 61 – K

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A61K 36/48 (2006.01) A61K 31/352 (2006.01) A61K 31/7048 (2006.01) G01N 33/50 (2006.01) G06F 17/10 (2006.01)

Patent

CA 2672408

The present invention provides a set of in vitro and in silico methodologies for predicting in vivo pharmacokinetics and pharmacodynamics of multiple components; the methodologies comprise mathematical models for solving multiple unknowns which are linearly independent and/or interacting with each other. The present invention can be applied to develop phytomedicines which contain multiple active ingredients without prior identification, isolation and purification of these components.

La présente invention concerne un ensemble de méthodologies in vitro et in silico pour prédire la pharmacocinétique et la pharmacodynamique in vivo de multiples composants; les méthodologies comprennent des modèles mathématiques pour résoudre de multiples inconnues qui sont linéairement indépendantes et/ou interagissant entre elles. La présente invention peut être appliquée pour développer des phytomédicaments qui contiennent de multiples principes actifs sans identification, isolement et purification préalables de ces composants.

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