A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/137 (2006.01) A61K 9/22 (2006.01)
Patent
CA 2592269
The present invention is directed to a controlled-release pharmaceutical composition providing a sustained delivery of the basic drug Terbutaline sulfate, said composition comprising at least Terbutaline sulfate or a derivative thereof as an active agent, and further comprising an inactive matrix, said matrix comprising a hydrophilic polysaccharide polymer mixture, said mixture comprising chitosan or a derivative thereof, and further comprising xanthan gum or a derivative thereof, wherein the ratio of xanthan gum and chitosan within said mixture is in the range from about 1:10 to about 10:1, and said composition optionally comprising sodium bicarbonate.
L'invention concerne une composition pharmaceutique à libération progressive assurant une libération continue du médicament de base sulfate de terbutaline, ladite composition contenant au moins du sulfate de terbutaline ou un dérivé de celui-ci en tant que principe actif, ainsi qu'une matrice inactive, ladite matrice comprenant un mélange polymère de polysaccharide hydrophile, ledit mélange contenant du chitosane ou un dérivé de celui-ci, ainsi que de la gomme xanthane ou un dérivé de celle-ci, le rapport gomme xanthane/chitosane du mélange se situant dans un intervalle compris approximativement entre 1:10 et 10:1, et ladite composition contenant éventuellement du bicarbonate de sodium.
Al-Remawi Mayyas
Badwan Adnan
Shapiro Cohen
The Jordanian Pharmaceutical Manufacturing Co.
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