A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/164, 167/253
A61K 31/60 (2006.01) A61K 9/30 (2006.01) A61K 9/50 (2006.01)
Patent
CA 1200762
ABSTRACT According to the present invention an oral pharmaceutical preparation of acetylsalicylic acid is provided which con- sists of cores containing acetylsalicylic acid as pharma- ceutically active component, which cores are coated with a polymer membrane to the formation of coated granules. The preparation is characterized in that the polymer membrane comprises at least one polymer selected from the group consisting of cellulose acetate phtalate and methyl esteri- fied methacrylic acid polymers having a degree of esterifi- cation of 45-55 %, whereby the amount of such polymer forms 60-45 % of the weight of the membrane, and at least one methyl esterified methacrylic acid polymer having a degree of esterification of 65-75 % and forming 45-25 % of the weight of the membrane, and a plasticizer selected from fatty alcohols and fatty acids forming 4-12 % of the weight of the membrane, whereby the membrane represents 5-12 weight-% of the composition. With this composition a reduced effect on the gastric mucosa as compared with previously known preparations but retaining good absorbtion properties and a controlled release.
401018
Appelgren Curt H.
Bogentoft Conny B.
Ekenved Gunnar H.
Aktiebolaget Hassle
Fetherstonhaugh & Co.
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