Pharmaceutical preparation

Details Pharmaceutical preparation Pharmaceutical preparation

A - Human Necessities

61

K

167/153

A61K 47/30 (2006.01) A61K 9/14 (2006.01) A61K 9/48 (2006.01) C07C 51/15 (2006.01) C07C 57/30 (2006.01)

Patent

CA 2016888

Abstract The invention discloses a pharmaceutical preparation consisting of one or more active substances and a vehicle (carrier) which solidifies in the range between 20° and 80°C and is water-soluble, characterized in that it is an isotropic solution, a) the active substance being dissolved in the vehicle in monomolecular form or as ion, b) the active substance being present in its native conformation and/or its biologically active chiral (enantiomeric) conformation, c) the active substance having a molar fraction of 0.001 to 0.67 at 37°C, d) the vehicle being molten, phase-uniform and iso- tropic at body temperature, e) the isotropic solution, consisting of vehicle and active substance, solidifying at room temp- erature, f) the solidified solution being crystalline or non- crystalline or containing the active substance in crystalline form or being able to crystallize out said active substance, g) the monomolecular or ionic solution having an os- motic pressure and effecting a molar freezing point reduction, h) the dissolved active substance having within the polymer electrolyte a temperature-dependent diff- usion coefficient and a temperature-dependent specific conductivity and a process for the preparation thereof.

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