Pharmaceutical preparation for the alleviation of endometriosis

Details Pharmaceutical preparation for the alleviation of endometriosis Pharmaceutical preparation for the alleviation of endometriosis

A - Human Necessities

61

K

A61K 31/57 (2006.01) A61K 31/573 (2006.01) A61P 15/00 (2006.01)

Patent

CA 2673936

A pharmaceutical composition for the treatment of endometriosis without loss of bone density comprises a gestagenic having an antiandrogenic effect, preferably 17.alpha.-cyanomethyl-17ß-hydroxy-estra-4,9-diene-3-one (Dienogest), cyproteronacetate or chlormadinonacetate at a daily dosage which is no more than two times the dosage required to suppress ovulation, together with one or a plurality of pharmaceutically acceptable adjuvants/carriers. The pharmaceutical composition according to the invention provides both the alleviation of endometriosis and the lack of a negative affect on bone metabolism and bone density, and is simultaneously able to keep the side effects known from conventional pharmaceuticals (such as hot flashes, acne, negative affects on the lipid profile) within tolerable limits. The pharmaceutical composition is thus suitable for long-term application.

La présente invention concerne une composition pharmaceutique conçue pour traiter une endométriose sans réduire la densité osseuse. Cette composition contient un gestagène anti-androgène, de préférence 17.alpha.-cyanométhyl-17-ß-hydroxyestra-4,9-dièn-3one (dienogest), acétate de cyprotérone ou acétate de chlormadinone, dans une dose journalière qui est au maximum deux fois supérieure à la dose d'inhibition d'ovulation, avec un ou plusieurs adjuvants/supports pharmaceutiquement acceptables. La composition pharmaceutique selon cette invention permet de traiter une endométriose sans influencer négativement le métabolisme osseux, ni la densité osseuse, et permet en même temps de maintenir à un niveau acceptable les effets secondaires connus (par ex. bouffées de chaleur, acné, influence négative sur le profil lipidique) engendrés par les médicaments classiques. Ladite composition pharmaceutique est par conséquent adaptée à une application à long terme.

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