Pharmaceutical preparation in the form of liposomes

Details Pharmaceutical preparation in the form of liposomes Pharmaceutical preparation in the form of liposomes

A - Human Necessities

61

K

A61K 47/24 (2006.01) A61K 9/127 (2006.01) A61K 31/57 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01)

Patent

CA 2253285

The invention relates to a pharmaceutical preparation in the form of liposomes, suitable for solubilisation of hardly soluble drugs, in particular of hardly soluble neurokinin antagonists, such as (+)-campher-3-carbonyl-(2S, 4R)-4-hydroxypyrolyl-(2S)-2-naphthylalanyl-(2-methoxyphenyl)piperazid or 1- methylindol-3-yl-carbonyl-[4(R)-hydroxy]-L-prolyl[3-(2-naphthyl)]-L-alanine-N- benzyl-N-methylamide.

L'invention concerne une préparation pharmaceutique sous forme de liposomes, appropriée pour la solubilisation de médicaments de faible solubilité, en particulier d'antagonistes de la neurokinine difficilement solubles, tels que, par exemple, le (+)-camphro-3-carbonyl-(2S, 4R)-4-hydroxypyrolyl-(2S)-2-naphtylalanyl-(2-méthoxyphényl)pipérazide ou le 1-méthylindol-3-yl-carbonyl-[4(R)-hydroxy]-L-prolyl-[3-(2-naphtyl)]-L-alanine-N-benzyl-N-méthylamide.

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