Pharmaceutical preparations

C - Chemistry – Metallurgy – 07 – J

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195/32, 260/65

C07J 5/00 (2006.01)

Patent

CA 1037026

ABSTRACT This invention is concerned with improvements in or relating to pharmaceutical preparations having anaesthetic activity, and more particularly aqueous preparations suitable for intravenous injection. The preparations comprise solutions of the known anaesthetic steroid 3.alpha.-hydroxy-5.alpha.-pregnane- 11,20-dione in aqueous solutions of parenterally acceptable non-ionic surface active agents. The preparations also contain certain new 21-acyloxy-3.alpha.-hydroxy- 5.alpha.-pregnane-11,20-diones which act as solubility promoters and constitute a further feature of the invention. Preferred classes of surface active agent are described and the useful materials fall within the class having an HLB value of at least 9, preferably from 9 to 18. Processes for preparing the preparations are described and claimed. A process for the preparation of the 21-acyloxy-3.alpha.-hydroxy-5.alpha.-pregnane-11,20-diones is described.

217940

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