Pharmaceutical preparations and their manufacture

Details Pharmaceutical preparations and their manufacture Pharmaceutical preparations and their manufacture

A - Human Necessities

61

K

A61K 9/113 (2006.01) A61K 9/16 (2006.01) A61K 9/51 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2404367

A method for making a composition comprising active particles comprising an active substance comprises the steps of a) providing an emulsion having a dispersed phase comprising a solution of the active substance in a solvent and b) inducing the formation, in the emulsion, of solid particles comprising the active substance. The particles may be isolated from the emulsion. Active particles having a normalized kurtosis of at least 5 and a mean diameter of less than 100 µm are provided.

Procédé de fabrication d'une composition renfermant des particules actives comprenant une substance active, caractérisé a) en ce qu'un prépare une émulsion ayant une phase dispersée renfermant une solution de la substance active dans un solvant, et b) en ce qu'on provoque la formation, dans l'émulsion, de particules solides renfermant la substance active. Les particules peuvent être séparées de l'émulsion. On obtient ainsi des particules actives ayant un aplatissement normalisé d'au moins 5 et un diamètre moyen inférieur à 100 µm.

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