Pharmaceutical preparations containing a polymeric agent for...

Details Pharmaceutical preparations containing a polymeric agent for... Pharmaceutical preparations containing a polymeric agent for...

C - Chemistry, Metallurgy

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C08F 8/30 (2006.01) A61K 31/785 (2006.01) A61K 31/795 (2006.01) A61K 47/48 (2006.01) C08F 8/34 (2006.01) C08G 65/334 (2006.01) C08G 65/48 (2006.01) C08G 85/00 (2006.01)

Patent

CA 1130281

P-189G FOREIGN MASTER PHARMACEUTICAL PREPARATIONS CONTAINING A POLYMERIC AGENT FOR RELEASING 5-AMINOSALICYLIC ACID OR ITS SALTS INTO THE GASTROINTESTINAL TRACT ABSTRACT OF THE DISCLOSURE An intestinal anti-inflammatory preparation comprising a polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed. The polymeric agent comprises a nonabsorb- able pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate's salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymers' azo bonds undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.

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