Pharmaceutical preparations having an improved solubility

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/08 (2006.01) A61K 9/16 (2006.01) A61K 47/20 (2006.01) A61K 47/22 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/36 (2006.01) A61K 47/40 (2006.01)

Patent

CA 2536283

A process for producing a medicinal preparation having improved dissolution properties which comprises dissolving a hardly soluble drug capable of forming a micelle in water to thereby form a micelle, and then stabilizing the micelle structure, which has been formed by the hardly soluble drug, with the use of a compound stabilizing a micelle structure. This process preferably includes the step of, after stabilizing the micelle structure, adjusting the pH value to the neutral level and/or adjusting the temperature to room temperature. The hardly soluble drug to be employed in this process is a drug that forms a micelle in water exclusively in the presence of an acid or an alkali and/or under heating. According to this production process, the oral absorbability of a hardly soluble drug can be improved. Thus, a medicinal preparation having improved dissolution properties can be produced.

L'invention concerne un procédé de production d'une préparation médicinale possédant de meilleures propriétés de dissolution, qui consiste à former une micelle en dissolvant un médicament difficilement soluble susceptible de former une micelle dans de l'eau, et à stabiliser la structure de micelle ainsi formée au moyen du médicament difficilement soluble, à l'aide d'un composé stabilisant une telle structure. De préférence, ce procédé consiste, après stabilisation de la structure de micelle, à régler la valeur de pH au niveau neutre et/ou à régler la température à la température ambiante. Dans ce procédé, le médicament difficilement soluble est un médicament qui forme une micelle dans de l'eau exclusivement en présence d'un acide ou d'un alcali et/ou sous l'effet de la chaleur. Selon ce procédé de production, l'absorbabilité d'un médicament difficilement soluble est améliorée. Ainsi, on peut produire une préparation médicinale présentant de meilleures propriétés de dissolution.

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