Pharmaceutical preparations of bioactive substances...

A - Human Necessities – 61 – K

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A61K 36/77 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 36/00 (2006.01) A61K 36/18 (2006.01) A61K 36/21 (2006.01) A61K 36/32 (2006.01) A61K 36/36 (2006.01) A61K 36/48 (2006.01) A61K 36/61 (2006.01) A61K 36/67 (2006.01) A61K 36/734 (2006.01) A61P 1/04 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 15/00 (2006.01) A61P 19/02 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (200

Patent

CA 2414094

This invention relates to methods of extracting and purifying bioactive substances from various plants and herbs. More specifically the invention relates to methods of extracting and separating bioactive substances from various plants and herbs, such as Kava root, Byrsonima species, Aesculus californica, Crataegus mexicana, Simmondsia chinensis, Pfaffia species, Alternanthera repens, Bursera species, Turnera species, Perezia species, Heimia salicifolia, Psidium species, Enterlobium species, Ptychopetalum olacoides, Liriosma ovata, and Chaunochiton kappleri, using supercritical fluid extraction and/or fluorocarbon solvent extract. The present invention further relates to separation of bioactive substances contained in extracts using packed column supercritical fluid chromatography or HPLC where dense gas with or without modifiers is the mobile phase. The present invention also relates to pharmaceutical preparations and dietary supplements which may be prepared with the extracted bioactive substances and use of such pharmaceutical preparations and dietary supplements to treat various human aliments.

La présente invention concerne des procédés d'extraction et de purification de substances bioactives à partir de plantes et d'herbes variées. Plus spécifiquement, cette invention concerne des procédés d'extraction et de séparation de substances bioactives à partir de plantes et d'herbes variées, telles que les racines de Kava, l'espèce Byrsonima, Aesculus californica, Crataegus mexicana, Simmondsia chinensis, l'espèce Pfaffia, Alternanthera repens, l'espèce Bursera, l'espèce Turnera, l'espèce Perezia, Heimia salicifolia, l'espèce Psidium, l'espèce Enterlobium, Ptychopetalum olacoides, Liriosma ovata, et Chaunochiton kappleri, en utilisant l'extraction avec fluide supercritique et/ou un extrait de solvant fluorocarboné. En outre, cette invention concerne la séparation de substances bioactives contenues dans les extraits en utilisant la chromatographie à fluide supercritique sur colonne garnie, ou HPLC, où le gaz dense avec ou sans modificateurs représente la phase mobile. En outre, cette invention concerne des préparations pharmaceutiques et des suppléments alimentaires pouvant être préparés avec ces substances bioactives extraites, et concerne enfin l'utilisation de ces préparations pharmaceutiques et suppléments alimentaires pour traiter des aliments humains variés.

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