Pharmaceutical product and methods and apparatus for making...

A - Human Necessities – 61 – K

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Details

A61K 9/70 (2006.01) A61J 3/00 (2006.01) B65B 1/04 (2006.01) B65B 1/30 (2006.01) B65B 11/50 (2006.01) A61J 1/03 (2006.01) B05B 5/08 (2006.01)

Patent

CA 2333107

The present invention provides a product (1) that includes a pharmaceutical unit dosage or diagnostic form (6) that includes at least one active ingredient that is present in an amount that advantageously does not vary by more than about five percent from a predetermined target amount. In one embodiment, the unit form comprises a substrate (8), a deposit (14) that is disposed on the substrate and a cover layer (9) that overlies the deposit and is joined to the substrate by a bond that encircles that deposit, thereby encapsulating it between the substrate and cover substrates. The deposit comprises a powder, at least some of which includes the at least one active ingredient. The unit form is created via a dry powder deposition apparatus that electrostatically deposits the powder on the substrate utilizing an electrostatic chuck and charged powder delivery apparatus.

La présente invention concerne un produit (1) pharmaceutique, en l'occurrence une monodose thérapeutique ou une dose de diagnostic (6) comprenant une quantité définie d'un principe actif ne s'écartant pas de plus de 5% de la quantité définie. Selon une réalisation, la monodose est constituée d'un substrat (8), d'un dépôt (14) sur le substrat, et d'une couche (9) qui recouvre le dépôt et qui est fixée au substrat par une liaison encerclant le dépôt et donc encapsulant le dépôt entre le substrat et les substrats de couverture. Le dépôt renferme une poudre dont une partie au moins est constituée du principe actif considéré. La monodose est obtenue au moyen d'un appareil de dépôt de poudre sèche qui procède à un dépôt électrostatique de la poudre sur le substrat. Cet appareil qui fait intervenir un mandrin électrostatique et un appareil de débit de poudre chargée, comporte également un appareil capable de mesurer la quantité de poudre déposée.

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