Pharmaceutical salts of 3-o-(3',3'-dimethylsuccinyl)...

Details Pharmaceutical salts of 3-o-(3',3'-dimethylsuccinyl)... Pharmaceutical salts of 3-o-(3',3'-dimethylsuccinyl)...

C - Chemistry, Metallurgy

07

J

C07J 53/00 (2006.01) A61K 31/56 (2006.01)

Patent

CA 2560266

Salts of 3-O-(3',3'-dimethylsuccinyl)Betulinic acid (DSB) are disclosed. Particularly, the preparation, pharmaceutical evaluation, and in vivo bioavailability evaluation of N-methyl-D-glucamine and alkali metal salt forms of DSB are disclosed. Pharmaceutical compositions including these salt forms are used in methods of treating HIV and related diseases. Methods of making the salts of DSB and the pharmaceutical compositions are also provided.

L'invention concerne des sels de l'acide 3-<I>O</I>-(3',3'-diméthylsuccinyl)bétulinique (DSB). Cette invention concerne, en particulier, la préparation, l'évaluation pharmaceutique et l'évaluation de la biodisponibilité in vivo de formes salines de N-méthyl-D-glucamine et de métaux alcalins de DSB. Des compositions pharmaceutiques contenant ces formes salines sont utilisées dans des méthodes de traitement du VIH et de maladies associées. Ladite invention concerne également des procédés pour produire ces sels de DSB et lesdites compositions pharmaceutiques.

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