Pharmaceutical screens and antibodies

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/18 (2006.01) A61K 49/00 (2006.01) C07K 14/47 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2115900

Abstract This invention describes a series of assays useful in evaluating the efficacy of agents which inhibit the neurotoxic effects of .beta.-amyloid peptide. These assays employ .beta.-amyloid peptide which is in a predominantly .beta.- sheet conformation. This invention also encompasses antibodies having a specificity for .beta.-amyloid peptide which is predominantly in a .beta.-sheet conformation as well as pharmaceutic formulations containing these antibodies. These antibodies show poor reactivity with .beta.-amyloid peptide which has a great deal of random coil or .alpha.-helix secondary structure.

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