A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/19 (2006.01) A61K 45/06 (2006.01) A61K 47/34 (2006.01)
Patent
CA 2665604
The present invention provides novel pharmaceutical solid dosage forms for oral administration comprising a therapeutically effective amount of an unstable crystalline form or an amorphous form of a therapeutically effective compound micro-embedded into an ionic water-insoluble polymer. The therapeutically effective compounds, which have a tendency to gel, are micro-embedded into an ionic water-insoluble polymer matrix to provide a dosage form having rapid, reproducible, and complete dissolution profiles. These novel solid pharmaceutical dosage forms are useful in the treatment or control of a number of diseases.
La présente invention concerne de nouvelles formes posologiques pharmaceutiques solides à usage oral contenant une quantité thérapeutiquement efficace d'une forme cristalline instable d'un composé sous forme amorphe, thérapeutiquement efficace, et micro-incorporé dans un polymère ionique insoluble dans l'eau. Les composés thérapeutiquement efficaces, qui ont tendance à se gélifier, sont micro-incorporés dans une matrice de polymère ionique insoluble dans l'eau afin de créer une forme posologique présentant des profils de dissolution rapide, reproductible et complète. Ces nouvelles formes posologiques pharmaceutiques solides se révèlent utiles pour le traitement ou la régulation d'un certain nombre de maladies.
Albano Antonio Aquino
Phuapradit Wantanee
Shah Navnit Hargovindas
Yu Zhongshui
Zhang Lin
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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