A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/10 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2470912
A pharmaceutical composition suitable for oral administration is provided, the composition comprising an aqueous medium having suspended therein a solid substance of low water solubility in particulate form, and further comprising a suspending agent and at least one pharmaceutically acceptable water-soluble or swellable nonsurfactant polymer, the total amount of all such polymers present being ineffectibve to (a) increase viscosity of the composition to a degree that significantly impairs pourability, or (b) significantly increase rate of sedimentation or phase separation, of the composition. The composition has improved mouth feel.
Cette composition pharmaceutique, se prêtant bien à une administration orale, se compose d'un milieu aqueux renfermant une suspension d'une substance à l'état solide peu soluble dans l'eau sous sa forme particulaire, d'un agent de suspension et d'au moins un polymère non tensioactif hydrosoluble ou se gonflant au contact de l'eau, acceptable du point de vue pharmaceutique. La quantité totale de tous ces polymères n'est pas suffisante, (a), pour augmenter notablement la viscosité de la composition jusqu'à altérer sa facilité à s'écouler ou, (b), pour accélérer de manière significative la vitesse de sédimentation ou la séparation des phases de la composition. De surcroît, les sensations en bouche de cette composition sont meilleures.
Chiang Po-Chang
Lu Guang Wei
Pharmacia Corporation
Smart & Biggar
LandOfFree
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