Pharmaceutical sustained release compositions comprising in...

Details Pharmaceutical sustained release compositions comprising in... Pharmaceutical sustained release compositions comprising in...

A - Human Necessities

61

K

A61K 31/195 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61P 5/14 (2006.01) A61P 9/04 (2006.01)

Patent

CA 2634006

There is provided sustained release pharmaceutical compositions comprising a drug; microcrystalline cellulose; a diluent (such as starch); a glidant (such as talc); and one or more of ethylcellulose, stearic acid and a salt of stearic acid. Preferred drugs include those that exhibit a low degree of solubility combined with a high potency, particularly thyroid hormones, such as liothyronine.

La présente invention concerne des compositions pharmaceutiques à libération prolongée comprenant un médicament; de la cellulose microcristalline; un diluant (tel que l'amidon); un glissant (tel que le talc); et un ou plusieurs parmi l'éthylcellulose, l'acide stéarique et un sel d'acide stéarique. Des médicaments préférés comprennent ceux qui présentent un faible degré de solubilité combiné avec une puissance élevée, en particulier des hormones thyroïdiennes, telles que la liothyronine.

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