Pharmaceutical use for secreted bacterial effector proteins

Details Pharmaceutical use for secreted bacterial effector proteins Pharmaceutical use for secreted bacterial effector proteins

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 39/02 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) C07K 14/195 (2006.01) C07K 14/24 (2006.01) C07K 14/255 (2006.01) C07K 17/00 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2448963

A polypeptide conjugate contains a bacterial injectable effector protein, secreted by a modified pilus or "needle-like" structure comprising a type III or type IV secretion apparatus, and a carrier that targets the conjugate to a target cell. The effector protein is used for a variety of purposes including treatment of neurodegenerative disease, intracellular infection and diseases associated with defects of secretion.

Un conjugué de polypeptides contient une protéine effectrice injectable bactérienne, sécrétée par une structure modifiée pileuse ou une aiguille comprenant un appareil de sécrétion de type III ou de type IV, et un support qui envoie le conjugué sur une cellule cible. La protéine effectrice est utilisée à des fins multiples y compris le traitement de maladies neurodégénératives, d'infections intracellulaires et de maladies associées à des défauts de sécrétion.

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