C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/08 (2006.01) A61K 31/4184 (2006.01) A61K 31/439 (2006.01) A61K 31/46 (2006.01) A61K 31/55 (2006.01) A61P 3/00 (2006.01) A61P 25/00 (2006.01) C07D 235/08 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 451/02 (2006.01) C07D 471/08 (2006.01)
Patent
CA 2627307
The use of substituted amides for modulating the activity of 11-hydroxysteroid dehydrogenase type 1 (11HSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11HSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.
L'invention concerne l'utilisation d'amides substitués aux fins de modulation de l'activité de la 11-hydroxystéroïde déshydrogénase de type 1 (11HSD1) et l'utilisation de ces composés comme compositions pharmaceutiques. L'invention concerne également une classe d'amides substitués, l'utilisation de ceux-ci dans un traitement, des compositions pharmaceutiques comprenant les composés et l'utilisation de ceux-ci dans la fabrication de médicaments. Les composés selon l'invention sont des modulateurs et, plus précisément, des inhibiteurs de l'activité de la 11HSD1 et peuvent être utiles dans le traitement, la prévention et/ou la prophylaxie d'une palette de troubles médicaux pour lesquels une concentration intracellulaire diminuée de glucocorticoïde est souhaitée.
Andersen Henrik Sune
Ebdrup Soren
Kampen Gita Camilla Tejlgaard
Kilburn John Paul
High Point Pharmaceuticals Llc
Smart & Biggar
Transtech Pharma Inc.
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