C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/36 (2006.01) A61K 31/44 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2655282
A novel class of compounds of the general formula (I) and (Ia), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11.beta.- hydroxysteroid dehydrogenase type 1 (11.beta.HSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, e.g. the metabolic syndrome.
La présente invention concerne une nouvelle classe de composés de formule générale (I) et (Ia), leur utilisation en thérapie, des compositions pharmaceutiques comprenant les composés, ainsi que leur utilisation dans la fabrication de médicaments. Les présents composés modulent l'activité de la 11.beta.-hydroxystéroïde déshydrogénase de type 1 (11.beta.HSD1) et sont en conséquence utiles dans le traitement de maladies dans lesquelles une telle modulation est bénéfique, par exemple, le syndrome métabolique.
Andersen Henrik Sune
Kampen Gita Camilla Tejlgaard
Kilburn John Paul
Andersen Henrik Sune
High Point Pharmaceuticals Llc
Kampen Gita Camilla Tejlgaard
Kilburn John Paul
Smart & Biggar
LandOfFree
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