A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/44 (2006.01) C07D 213/22 (2006.01) C07D 213/26 (2006.01) C07D 213/30 (2006.01) C07D 213/38 (2006.01) C07D 213/55 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2152777
A terpyridine derivative represented by formula (I): Image (I) wherein R represents a hydrogen atom; a substituted or unsubstituted phenyl group, pyridyl group, etc., which has a nerve growth factor synthesis-stimulating activity or a neurotrophic activity. Accordingly, the terpyridine derivative can be used for improving or treating conditions or diseases associated with traumatic, chemical (alcohol or carcinostatic agents), inflammatory, metabolic (observed in diabetes, etc.) or idiopathic denaturation of peripheral nerves. The terpyridine derivatives of the present invention may also be used as drugs for the improvement and treatment of psychological malfunction, locomotor malfunction or paravertebral anesthesia, etc., caused by conditions or diseases associated with denaturation of central nerves, e.g., Alzheimer and cerebro-vascular dementia, Down's syndrome, Parkinson's disease, Huntington's chorea, cerebral ischemia, cerebral infarction, head trauma, and the like.
Hanabusa Kenji
Hanada Kazunori
Mizobe Fumio
Shirai Hirofusa
Takahashi Yuki
Mccarthy Tetrault Llp
Taisho Pharmaceutical Co. Ltd.
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