Pharmaceutically acceptable composition comprising an...

Details Pharmaceutically acceptable composition comprising an... Pharmaceutically acceptable composition comprising an...

A - Human Necessities

61

K

A61K 31/337 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2362338

An optically clear, pharmaceutically acceptable aqueous composition comprising paclitaxel or a derivative thereof, serum albumin and a pharmaceutically acceptable vehicle, wherein the composition comprises no more than 10 % organic solvent and has a pH of about 3.0 to about 4.8, is described. The serum albumin can be fatted or defatted, and the composition can optionally be lyophilized or optionally lyophilized and reconstituted. At least 70 % of the paclitaxel is bound to serum albumin, the ratio of paclitaxel to albumin is at least about 1:5, and the concentration of paclitaxel is at least about 25 µg/ml. Methods of making and using this composition are also provided.

L'invention concerne une composition aqueuse pharmaceutiquement acceptable, optiquement claire, comprenant du paclitaxel ou un dérivé de celui-ci, une albumine sérique et un excipient pharmaceutiquement acceptable, cette composition comprenant au maximum 10 % de solvant organique, et présentant un pH d'environ 3,0 à 4,8. L'albumine sérique peut être grasse ou dégraissée, et la composition peut, éventuellement, être lyophilisée ou lyophilisée et reconstituée. Au moins 10 % du paclitaxel est lié à une albumine sérique, le rapport paclitaxel-albumine étant d'au moins 1/5, et la concentration du paclitaxel étant d'au moins 25µg/ml. L'invention concerne également des procédés permettant de préparer et d'utiliser cette composition.

Affiliated with

Also associated with

Rating

Pharmaceutically acceptable composition comprising an... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutically acceptable composition comprising an..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutically acceptable composition comprising an... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1527067