Pharmaceutically acceptable dnase formulation

Details Pharmaceutically acceptable dnase formulation Pharmaceutically acceptable dnase formulation

C - Chemistry, Metallurgy

12

N

C12N 9/96 (2006.01) A61K 9/12 (2006.01) A61K 38/46 (2006.01) C12N 9/16 (2006.01)

Patent

CA 2184582

The present invention describes methods and means for preparing pharmaceutically acceptable formulations of DNase via spray-drying solutions comprising said DNase and a compatible excipient under conditions such that a dry powder containing DNase is produced. Such products of spray drying result in the exhibition of properties known to be essential for therapeutic effectiveness when the formulations are administered by dispersion into the lung of an individual patient. The therapeutic effect results in the DNase effecting enzymatic alteration of the viscoelasticity of mucus within the lung of the individual so treated.

La présente invention se rapporte à des procédés et à des moyens de préparation de formulations pharmaceutiquement acceptables de DNase par des solutions de séchage par atomisation comprenant cette DNase et un excipient compatible dans des conditions permettant d'obtenir une poudre sèche contenant la DNase. Ces produits de séchage par atomisation apportent des propriétés connues pour être essentielles dans l'efficacité thérapeutique lorsque les formulations sont administrées par dispersion dans le poumon d'un patient. L'effet thérapeutique entraîne une modification enzymatique agissant sur la DNase de la viscoélasticité des mucosités dans le poumon d'un individu ayant subi ce traitement.

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