Pharmaceutically active agents that impede amyloid formation...

A - Human Necessities – 61 – K

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167/102, 167/202

A61K 31/00 (2006.01) A61K 31/35 (2006.01) A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01) A61K 31/63 (2006.01) A61K 31/655 (2006.01) A61K 31/70 (2006.01) C07H 17/08 (2006.01) C07H 19/06 (2006.01)

Patent

CA 2032141

Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation of amyloid fibrils associated with Alzheimer's disease and other forms of cerebral amyloidosis. Compounds that, at in- tissue concentrations of 10 -5 M or less, inhibit amyloid formation in a test animal injected intracerebrally with dense microspheres are particularly useful in inhibiting treating cerebral amyloidosis.

La présente invention se rapporte à des microsphères denses qui peuvent être extraites et épurées sous forme essentiellement homogène à partir de tissu du cerveau d'un mammifère et qui sont utilisées dans la prospection de thérapies potentiellement efficaces contre la formation de fibrilles d'amyloïde associées à la maladie Alzheimer et à d'autres formes de l'amyloïdose cérébrale. Ces composés qui, à des concentrations intratissulaires de 10-5 M ou moins, empêchent la formation d'amyloïde dans un animal test ayant subi une injection intracérébrale de ces microsphères denses, sont particulièrement utilisés dans le traitement inhibiteur de l'amyloïdose cérébrale.

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