C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/505 (2006.01)
Patent
CA 2078148
2078148 9113886 PCTABS00007 Novel pharmaceutically active compounds which can be formed from 1,3,4,6,7,8-hexahydro-2H-pyrimido-(1,2-a)-pyrimidine (HHPP) or an 1-alkyl (R) derivative thereof, wherein R is hydrogen or an alkyl group, preferably -CH3, and a residue of an acid or acid anhydride of classes comprising specific acids and acid anhydrides of an acid HA or H2A selected from indole carboxylic acid, preferably from 2-indole carboxylic acid, 2,4,6-trihydroxy benzaldehyde being made subject to oxidation, 3-nitro-o-toluic acid, phthalic anhydride and benzoic anhydride, or an ester or acid chloride thereof; the acid being further selected from 4-chloro-2-nitrobenzoic acid, 4-nitrophenylacetic acid, 2,4-dinitrophenylacetic acid, 5-chloro-2-nitrobenzoic acid, 4-chloro-3-nitrobenzoic acid, 5-nitrosalicylic acid, (2-hydroxy-5-nitrobenzoic acid), 3-hydroxy-4-nitrobenzoic acid, 2-iodobenzoic acid, 5-amino-5-hydroxybenzoic acid, 5-nitroisophthalic acid, (5-nitrobenzene-1, 3-dicarboxylic acid); an amino acid, such as a natural amino acid, such as selected from glycine, L-glutamine and L-histidine, and further such as an amino acid selected from L-valine, L-leucine, and 4-aminobutyric acid (GABA), L-glutamic acid, L-serine, L-lysine, L-proline, L-alanine, L-cysteine, L-4-hydroxyvaline, L-aspartic acid, L-phenylalanine, L-tryptophane, and L-methionine; boric acid; or a neutral amine salt of such a pharmaceutically active compound. The compounds have antiviral activity.
Dahlgren Ake
Dahlgren Atti-La
Institut Fur Sozial-Medizinische Forschung Sa
Ridout & Maybee Llp
LandOfFree
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