C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/283, 260/277
C07D 215/42 (2006.01) C07D 215/44 (2006.01)
Patent
CA 1077040
ABSTRACT OF THE DISCLOSURE: The invention relates to decahydroquinoline derivatives represented by the general formula: Image (I) and the pharmaceutically acceptable acid addition salts thereof, wherein R1 represents a branched- or straight-chain alkyl group or alkoxy group containing from 1 to 4 carbon atoms, or a phenyl, furyl or pyridyl group; R2 represents a branched- or straight- chain alkyl group containing from 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted by an alkyl or alkoxy group containing 1 to 4 carbon atoms, a naphthyl group, a benzyl or cyclohexyl group; and R3 represents a benzyl, phenethyl, cinnamyl or phenylpropyl group or a group of the formula: Image (II) wherein A represents a branched- or straight-chain alkylene group; Y represents an atom of oxygen or sulphur or a carbonyl group, n is zero or an integer of from 1 to 4, with the proviso that when n is zero, Y is a carbonyl group, R4 and R5 which are identical or different each represents an atom of hydrogen or halogen or a methyl or methoxy group. Certain compounds of formula (I) have been found to possess useful analgesic properties while others have been found to be potentially useful in the treatment of high blood pressure.
267706
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