Pharmaceutically active salt derivative of 3-hydroxy-...

Details Pharmaceutically active salt derivative of 3-hydroxy-... Pharmaceutically active salt derivative of 3-hydroxy-...

C - Chemistry, Metallurgy

07

F

167/231, 260/290

C07F 9/58 (2006.01) A61K 31/675 (2006.01)

Patent

CA 1262733

Abstract of the Disclosure The present invention relates to a novel pharmacolog- ically active salt derivative,constituted by 4-(1-pyrrolidin- yl)-1-(2,4,6-trimethoxy-phenyl)-1-butanone 3-hydroxy-5- (hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphate, to the process for the production thereof, and to the relat- ed pharmaceutical compositions. Said salt derivative is produced by reacting 3-hydroxy- 5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphoric acid with 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)- 3-butanone in an organic solvent and subsequently crystal- lizing the reaction product. Said salt derivative carries out an important pharma- cological activity as inhibitor of platelet aggregation with vasodilative action.

496746

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