C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/245, 167/250
C07F 9/09 (2006.01) A61K 31/08 (2006.01) A61K 31/66 (2006.01) C07F 9/24 (2006.01) C07F 9/655 (2006.01)
Patent
CA 1338627
Cytotoxically effective pharmaceutical which contains com- pounds of formula I R - Y - PO? - X - R1 or a physiologically compatible salt thereof, where in form- ula I R is a saturated or unsaturated hydrocarbon radical having from 12 to 24 carbon atoms, which can also be halogen substituted, X is an oxygen atom, NH or NR2 and Y is an oxy- gen atom or NH, R1 is a C1-C8-alkyl group, or where R1 is a C2-C8-alkyl group, which is unsaturated and/or is substituted with halogen, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, tri-C1-C6-alkylamino, hydroxy, carboxy, C3-C8-cycloalkyl or phenyl, and where R1 can also be 2-tert.-butyloxycarbonyl- aminoethyl, 2-tert.-butyloxycarbonylethyl, 2,3-isopropyidene- dioxi-propyl-(1), 2,3-dibenzyloxy-propyl-(1), 1,3 -dibenzyl- oxy-propyl-(2) or N-C1-C6-alkylamino-C2-C6-alkyl, when X is an oxygen atom and where R1 additionally can be 2,3-dihydroxy- propyl-(1), when X is the NH group, and R2 is a 2,3-dihydroxy- propyl-(1) group, a C1-C8-alkyl group or a C2-C8-alkyl group, which is unsaturated and/or is substituted with halogen, amino, C1-C6-alkylamino, di-C1C6-alkylamino, tri-C1-C6-alkylamino, hydroxy, carboxy, C3-C8-cycloalkyl or phenyl, compounds of formula I as well a process for their preparation.
524478
Eibl Hansjorg
Max Planck Gesellschaft Zur Forderung Der Wissenschaften E.v.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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