Pharmaceuticals containing acylated benzilic acid...

Details Pharmaceuticals containing acylated benzilic acid... Pharmaceuticals containing acylated benzilic acid...

C - Chemistry, Metallurgy

07

D

167/232, 260/292

C07D 211/46 (2006.01) A61K 31/445 (2006.01)

Patent

CA 1321591

Abstract of the Disclosure Certain acylated benzilic acid derivatives are useful for influencing therapeutically the tone of the urinary bladder in humans and animals. These derivatives are N-alkyl-4-piperidyl .alpha.,.alpha.-diphenyl-.alpha.- acyloxyacetates having the formula Image (I) wherein R is H, CH3, C2H5 or C3H7; R' is H, NH2, phenyl, carboxyphenyl, (C1-C6)alkyl, hydroxy(C1- C6)alkyl, methoxy, ethoxy, methoxymethyl, ethoxy- methyl, amino(C1-C6)alkyl which can be substituted in the alkyl radical by one or more of a -NH2, -COOH or -SCH3 group, N-acetylamino(C1-C6)alkyl, or a group having the formula - CH = CH-COOR" or - (CH2)n - COOR" where n is an integer from 0 to 8, and R" is H, CH3, C2H5, C3H7, or a pharmacologically acceptable cation; or a salt thereof with a pharmaceutically acceptable acid. -17-

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