C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0797 (2010.01) A61K 35/30 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2213780
Current sources of neural stem and progenitor cells for neural transplantation are essentially inaccessible in living animals. This invention relates to neural precursor cells (stem cells, progenitor cells or a combination of both types of cells) isolated from the olfactory epithelium of mammals that can be passaged and expanded, and that will differentiate into cell types of the central nervous system (CNS), including astrocytes, oligodendrocytes, and tyrosine-hydroxylase-positive neurons. These precursor cells provide an accessible source for autologous transplantation in CNS, PNS, spinal cord and other damaged tissues.
Il est pratiquement impossible à l'heure actuelle d'avoir accès aux sources de cellules souches et de progéniteurs cellulaires neuraux sur des animaux vivants aux fin d'une greffe neuronale. Cette invention porte sur des cellules nerveuses précurseurs (cellules souches, progéniteurs ou une combinaison des deux) isolées de l'épithélium olfactif de mammifères, qui peuvent être repiquées et multipliées, et qui se différencieront en types de cellules du système nerveux central (SNC), y compris en astrocytes, en oligodendrocytes et en neurones tyrosine-hydroxylase-positifs. Ces cellules précurseurs constituent une source accessible pour les autogreffes dans le SNC, le SNP, la moelle épinière et d'autres tissus endommagés.
Gloster Andrew
Miller Freda
Borden Ladner Gervais Llp
University Mcgill
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