Pharmaceuticals containing retinal stem cells

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/071 (2010.01) C12N 5/0735 (2010.01) C12N 5/074 (2010.01) A61K 35/44 (2006.01) A61K 38/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2216439

The invention relates to stem cells isolated from the retina of mammals and retinal cells differentiated from these stem cells. The invention also relates to a method of isolating retinal stem cells and inducing retinal stem cells to produce retinal cells. Retinal stem cells may also be induced in vivo to produce retinal cells. The invention also includes pharmaceuticals made with retinal stem cells or retinal cells which may be used to restore vision lost due to diseases, disorders or abnormal physical states of the retina. The invention includes retinal stem cell and retinal cell culture systems for toxicological assays, for isolating genes involved in retinal differentiation or for developing tumour cell lines.

L'invention porte sur des cellules souches isolées de la rétine de mammifères et sur des cellules rétiniennes différenciées de ces cellules souches. L'invention porte également sur une méthode pour isoler des cellules souches rétiniennes et induire ces dernières à produire des cellules rétiniennes. Les cellules souches rétiniennes peuvent aussi être induites in vivo à produire des cellules rétiniennes. L'invention porte aussi sur des produits pharmaceutiques, faits à partir de cellules souches rétiniennes ou de cellules rétiniennes, qui peuvent être utilisés pour rétablir la vision perdue à la suite de maladies, de troubles ou d'états anormaux de la rétine. L'invention comprend des cellules souches rétiniennes et des systèmes de culture des cellules rétiniennes pour des tests de toxicologie, pour l'isolement des gènes responsables de la différenciation des cellules rétiniennes ou pour la création de lignées de cellules tumorales.

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