Pharmacodynamic assay for inhibitors of...

Details Pharmacodynamic assay for inhibitors of... Pharmacodynamic assay for inhibitors of...

C - Chemistry, Metallurgy

12

Q

C12Q 1/32 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2515129

A novel method is provided to measure 11.beta.-hydroxysteroid dehydrogenase activity in intact whole animal tissues in the presence of systemically or ex vivo administered inhibitors of the enzyme. Inhibitors of the type 1 isoform (11.beta. -HSD1) may be useful to treat type 2 diabetes, Metabolic Syndrome, and other metabolic disorders.

Procédé nouveau permettant de mesurer l'activité 11-bêta-hydroxystéroïde déshydrogénase dans les tissus animaux entiers intacts en présence d'inhibiteurs de cette enzyme administrés de façon systémique ou ex vivo. Les inhibiteurs isoformes de type I (11.beta.-HSD1) peuvent être utiles dans le traitement du diabète non insulino-dépendant, le syndrome métabolique et d'autres troubles métaboliques.

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