Pharmacokinetic and pharmacodynamic modeling of...

A - Human Necessities – 61 – K

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A61K 38/18 (2006.01) G06F 17/00 (2006.01) A61K 38/12 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2372782

The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.

La présente invention concerne des systèmes et des méthodes permettant d'obtenir des posologies optimales d'érythropoïétine (EPO) pour une réponse pharmacodynamique/pharmacocinétique désirée. Ce système comprend la sélection d'une ou plusieurs posologies d'EPO, puis l'utilisation d'un modèle pharmacodynamique/pharmacocinétique (PK/PD) pour déterminer le profil pharmacodynamique/pharmacocinétique d'une ou plusieurs posologies d'EPO, et enfin, la sélection d'une des posologies d'EPO pour l'administration, afin d'atteindre la réponse pharmacodynamique/pharmacocinétique désirée à partir du profil d'EPO.

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