Pharmacokinetic-based culture system with biological barriers

Details Pharmacokinetic-based culture system with biological barriers Pharmacokinetic-based culture system with biological barriers

C - Chemistry, Metallurgy

12

M

C12M 3/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2607965

Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments (3722, 3734, 3744) that can be interconnected by microscale channels. Cells or cellular materials associated with the organs can be cultured in such compartments to allow interactions with drug compounds in one or more fluidic flows. Such fluidic systems can include, by way of examples, gastrointestinal flow, blood flow, bile flow, urinary flow, and brain fluid flow. Interactions between fluidic systems can be simulated by a microscale permeable member (3430). In one example, blood-biliary interaction can be simulated by a microscale permeable material having hepatocytes (3434) bound to a permeable substrate (3432) via a binder.

L'invention concerne des systèmes et des procédés se rapportant à la pharmacocinétique de petite échelle. Divers organes et leurs interactions avec des composés médicamenteux peuvent être simulés in vitro par utilisation de compartiments de petite échelle (3722, 3734, 3744) pouvant être reliés par des canaux de petite échelle. Des cellules ou des matériaux cellulaires associés aux organes peuvent être cultivés dans de tels compartiments pour permettre des interactions avec des composés médicamenteux dans un ou plusieurs débits fluidiques. De tels systèmes fluidiques peuvent comprendre, à titre d'exemple, un écoulement gastrointestinal, un débit sanguin, un débit biliaire, un débit urinaire, un débit de fluide cérébral. Des interactions entre des systèmes fluidiques peuvent être simulées par un élément perméable de petite échelle (3430). Dans un exemple, une interaction sang-bile peut être simulée par un matériau perméable de petite échelle comprenant des hépatocytes (3434) fixés à un substrat perméable (3432) par un lieur.

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