A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/47 (2006.01) A61K 31/472 (2006.01) A61P 27/06 (2006.01)
Patent
CA 2699599
A composition for controlling or preventing progression of glaucoma comprises a material that reduces or inhibits production of a TGF-.beta. isoform or a chemokine or cytokine that stimulates expression of a TGF-.beta. isoform. The material can comprise a dissociated glucocorticoid receptor agonist ("DIGRA"), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof. The composition can further comprise an antagonist to TGF-.beta.. It is administered to a patient who has undergone glaucoma filtration surgery to ensure a functioning filtering bleb following such surgery.
L'invention concerne une composition destinée à réguler ou à prévenir la progression du glaucome, et qui comprend une matière qui réduit ou inhibe la production d'un isoforme de TGF-ß, ou une chimiokine ou une cytokine qui stimule l'expression d'un isoforme de TGF-ß. Ladite matière comprend un agoniste des récepteurs de glucocorticoïdes dissociés ("DIGRA"), un promédicament de celui-ci, un sel pharmaceutiquement acceptable de celui-ci ou un ester pharmaceutiquement acceptable de celui-ci. La composition comprend en outre un antagoniste de TGF-ß, et est administrée à un patient ayant subi une intervention de chirurgie filtrante du glaucome afin de garantir la formation d'une bulle de filtration active après l'intervention chirurgicale.
Bausch & Lomb Incorporated
Osler Hoskin & Harcourt Llp
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