Pharmacological compositions based on cisplatinum and method...

Details Pharmacological compositions based on cisplatinum and method... Pharmacological compositions based on cisplatinum and method...

A - Human Necessities

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A61K 33/24 (2006.01) A61K 9/19 (2006.01) A61K 33/02 (2006.01) A61K 47/02 (2006.01)

Patent

CA 1211372

TITLE: Pharmacological Compositions ABSTRACT: Unit-dosage freeze-dried formulations of cisplatinum are prepared by dissolving a unit dose (usually 10 to 50 mg) of cisplatinum in an aqueous solution containing C1- ions (usually 45 to 450 mg of NaC1) at 35 to 45°C, dissolving any excipient in the solution, adjusting the pH to 3.2 to 4,0 with mineral acid, e.g. 1N HC1, adding 0.2 to 5% by volume of an alcohol, such as ethanol, isopropanol or t-butanol, adjusting the pH of the solution to 1.2 to 2 mg cisplatinum/ml, and freeze-drying the solution. The unit-dosage freeze-dried formulations, which are useful in anti-tumour therapy, are readily reconstituted with water for injection and are stable over long periods.

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