Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles...

Details Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles... Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles...

C - Chemistry, Metallurgy

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C07D 231/10 (2006.01) A61K 31/415 (2006.01) C07C 59/84 (2006.01) C07C 59/88 (2006.01) C07D 231/12 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1337122

1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and cardiovascular disorders in mammals. The above pyrazoles have the general formula Image wherein R1, R2, R3 and R4 represent hydrogen, amino, halo, nitro and various organic radicals such as lower alkyl; R is a straigth, saturated or unsaturated hydro- carbon that contains 2-16 carbon atoms; Y is hydrogen, bromo, chlore or lower alkyl having 1-4 carbon atoms; and X is a radical for example carboloweralkoxy, carboxy, cyano and the like.

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