C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/364, 260/279
C07D 307/78 (2006.01) C07C 45/71 (2006.01) C07D 307/80 (2006.01) C07D 333/56 (2006.01) C07F 1/08 (2006.01)
Patent
CA 1053673
ABSTRACT OF THE DISCLOSURE A compound is disclosed of the formula: Image or a pharmaceutically acceptable acid addition salt thereof, in which: R1 is phenyl, halophenyl, dihalophenyl, trihalophenyl, lower alkylphenyl, di-lower alkylphenyl, tri-lower alkylphenyl, lower alkoxyphenyl, di-lower alkoxyphenyl, tri-lower alkoxyphenyl, lower alkyl-di- lower alkoxyphenyl or lower alkoxy-di-lower alkylphenyl; R2 is hydrogen, halo, lower alkyl, lower alkoxy, nitro or trifluoromethyl; R3 is Image ; R4 is hydrogen, methyl, ethyl or propyl and R5 is methyl, ethyl or propyl or R4 and R5 together with the nitrogen atom to which they are attached form a pyrrolidine, piperidine, N-(lower alkyl)piperazine, morpholine or perhydroazepien ring; R6 is hydrogen or hydroxy; m is 0 or 1 when R6 is hydrogen and 1 when R6 is hydroxy; n is 0 or 1; and Z is oxygen or sulfur. These compounds have been found to have pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of anginapectoris.
223045
Brenner Leonard M.
Brush Charles K.
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