C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 401/00 (2006.01) C07D 413/00 (2006.01)
Patent
CA 2043640
ABSTRACT PHARMACOLOGICALLY ACTIVE CNS COMPOUNDS The invention provides a series of compounds of formula (I) Image (I) and salts thereof, wherein for example, R1 and R2, which may be the same or different each represent -NR13R14 where R13 and R14 may each independently represent hydrogen or alkyl or, taken together with the nitrogen atom to which they are attached form a heterocyclic ring, optionally substituted by one or more alkyl or arylalkyl groups and optionally containing a further heteroatom; R3 is hydrogen, haloalkyl, alkoxymethyl or alkyl; R4 is hydrogen, nitro or halo; R5 is hydrogen or halo; R6 is hydrogen, halo, nitro, amino, alkylamino or dialkylamino; R7 is hydrogen or halo; R8 is hydrogen or halo; The compounds may be used for the treatment or prophylaxis of a neurodegenerative or other neurological disorder of the CNS, the aetiology or which includes excessive release of the neurotransmitter glutamate. PA1156/Abstract
Iyer Ramachandran
Leach Michael John
Nobbs Malcolm Stuart
Skone Philip Alan
Yeates Clive Leonard
Swabey Ogilvy Renault
The Wellcome Foundation Limited
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