Pharmacologically active cyclopropane derivatives

Details Pharmacologically active cyclopropane derivatives Pharmacologically active cyclopropane derivatives

C - Chemistry, Metallurgy

07

D

260/602, 260/353

C07D 317/58 (2006.01) C07D 317/64 (2006.01)

Patent

CA 1178597

ABSTRACT OF THE DISCLOSURE Processes are provided for the preparation of novel cyclopropane derivatives of the formula Image wherein Ar is phenyl or phenyl monosubstituted or polysubstituted by F, C1, Br, C14 alkyl, C1-4 alkoxy, C2-4 alkenyloxy, C1-4 alkylthio, ON, SH, CN, methylenedioxy or CF3; and R is H, C1-4 alkyl or benzyl, or a physio- logically acceptable acid addition salt thereof. Such novel cyclopropan- derivatives have valuable pharmacological properties, e.g., as antidepres- sants.

377048

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