Pharmacologically active peptides

Details Pharmacologically active peptides Pharmacologically active peptides

C - Chemistry, Metallurgy

07

K

530/5.04

C07K 5/107 (2006.01) C07K 5/10 (2006.01)

Patent

CA 1187871

Abstract of the Disclosure Compounds of the formula Image (I) and pharmaceutically acceptable non-toxic acid addition salts thereof, in which R is hydrogen, methyl, ethyl, cyclopropyl- methyl, or allyl; A is a residue of a D-amino acid selected from Ala, Abu, Nva, Val, Nle, Leu, Ile, Gly(A1), Gly(Cp), Met, Cys(Me), Met(O), Cys(Me)(O), Ser, Thr, and Hse; R1 is C1-C3 primary alkyl, cyclopropylmethyl, allyl, ethylthiomethyl, 2-fluoroethyl, or propargyl; X is bromo, iodo, chloro, methyl, trifluoro- methyl, or methoxy; and Z is -CH2OR2, Image , or Image , in which R2 is hydrogen, acetyl, or acetoxymethyl and R3 is C1-C3 alkyl; which are useful analgesic agents, are described herein.

387762

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