Phase ii detoxification and antioxidant activity

Details Phase ii detoxification and antioxidant activity Phase ii detoxification and antioxidant activity

A - Human Necessities

61

K

A61K 36/76 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2699813

Provided are methods and compositions that enhance Nrf2 (SKN-1) activation of phase II detoxification or antioxidant enzyme transcription, comprising plant extracts (e.g., willow extracts) or active fractions thereof, as well as methods for identifying additional compounds that increase the Nrf2-regulation of those enzymes.

L'invention concerne des procédés et des compositions qui augmentent l'activation Nrf2 (SKN-1) de la transcription d'enzyme antioxydante ou de détoxification de phase II, comprenant des extraits végétaux (par exemple, des extraits de saule) ou des fractions actives de ceux-ci, ainsi que des procédés pour identifier des composés additionnels qui augmentent la régulation Nrf2 de ces enzymes.

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