Phase transitioning hydrogels

C - Chemistry – Metallurgy – 08 – L

Patent

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Details

C08L 29/04 (2006.01) A61L 27/26 (2006.01) A61L 27/52 (2006.01) C08K 3/30 (2006.01) C08L 39/06 (2006.01) C08L 71/02 (2006.01)

Patent

CA 2725087

A method of forming and the resulting hydrogel composition comprising poly(vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/ w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly( vinyl pyrrolidone) at a final concentration of about 0.10% (w/w) to about 0.75% (w/w).

L'invention concerne un procédé de préparation d'une composition d'hydrogel et la composition d'hydrogel résultante qui comporte de l'alcool polyvinylique à une concentration finale d'environ 20 % en poids jusqu'à environ 65 % en poids et du polyéthylèneglycol à une concentration finale d'environ 2 % en poids jusqu'à environ 20 % en poids, la composition d'hydrogel ayant une teneur totale en polymère au-dessus d'environ 30 % en poids, donc plus élevée que la teneur totale en polymère d'une solution de polymère précurseur formulée avant la formulation de la composition d'hydrogel. La composition hydrogel peut de plus comporter du polyvinylpyrrolidone à une concentration finale d'environ 0,10 % en poids jusqu'à environ 0,75 % en poids.

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