C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/48 (2006.01) A61K 31/135 (2006.01) A61K 31/165 (2006.01) A61K 31/47 (2006.01) C07C 211/27 (2006.01) C07C 215/50 (2006.01) C07C 217/58 (2006.01) C07C 217/60 (2006.01) C07C 233/05 (2006.01) C07C 233/18 (2006.01) C07C 233/65 (2006.01) C07C 235/34 (2006.01) C07D 217/04 (2006.01) C07D 217/06 (2006.01) C07D 217/24 (2006.01)
Patent
CA 2103367
Abstract of the Disclosure Phellodendrine analogs represented by the following formula (I), Image (I) wherein A represents a group Image , wherein B represents a hydrogen atom, a lower alkyl group, or a lower acyl group, or A and B may form, together with the adjacent nitrogen atom, a substituted 1,2,3,4-tetrahydroisoquinolyl ring represented by the following formula, Image , wherein R11, R12, R21, R22, R31 and R32 individually represent a hydrogen atom, a hydroxy group, or a lower alkoxy group, n1 is a number 0-2, n2 is 1 or 2, and m1 denotes a number 0-1, provided that when A is a group Image , 162 if n2 is 2, B is a lower acyl group, and further that when A and B together form a substituted 1,2,3,4- tetrahydroisoquinolyl ring, n1 is 1 and m1 is not 0. Since the phellodendrine analogs (I) and related compounds thereof exhibit an excellent allergy type IV suppressing action, they can be used as a drug effective for curing diseases involving allergy type IV, such as chronic hepatitis, intractable asthma, nephrotic syndrome, rheumatism, and the like. 163
Fujisawa Shinichi
Hosaka Kunio
Kawamura Hideki
Koda Akihide
Matsuoka Yoshiyuki
Gowling Lafleur Henderson Llp
Tsumura & Co.
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